Preparation and evaluation of lipid polymer nanoparticles for eradicating H. pylori biofilm and impairing antibacterial resistance in vitro.
Preparation and evaluation of lipid polymer nanoparticles for eradicating H. pylori biofilm and impairing antibacterial resistance in vitro.
Jie Cai,Huizhi Huang,6 Autori,Chuanbin Wu
2015 · DOI: 10.1016/j.ijpharm.2015.09.055
International journal of pharmaceutics · 75 citazioni
TLDR
It is concluded that employing the mixed lipids of rhamnolipid and phospholipids as the outer layer of nanoparticles and PECS as the inner core produces a system capable of significantly disrupting H. pylori biofilm by eliminating the EPS as well as inhibiting the adherence and colonization of bacteria.