Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
Weina Zhang,Guihua Wang,23 Autori,Hui-Kuan Lin
2019 · DOI: 10.1016/j.cell.2019.05.003
Cell · 459 citazioni
TLDR
It is shown that lactate reduction by lactate dehydrogenase A (LDHA) inactivation heightens type I IFN production to protect mice from viral infection and identifies MAVS as a direct sensor of lactate, which functions to connect energy metabolism and innate immunity.