Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
Energy Metabolism in a Matched Model of Radiation Resistance for Head and Neck Squamous Cell Cancer
Jade Mims,Nidhi Bansal,4 Autori,C. Furdui
2015 · DOI: 10.1667/RR13828.1
Radiation Research · 97 citazioni
TLDR
Inhibition of fatty acid synthase with orlistat or FASN siRNA resulted in increased cytotoxicity and sensitivity to radiation in rSCC-61 cells, demonstrating the potential of combination therapy using radiation and orlistats or other inhibitors of lipid and energy metabolism for treating radiation resistance in HNSCC.