RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
Jordina Guillén-Boixet,Andrii Kopach,20 Autori,Titus M. Franzmann
2020 · DOI: 10.1016/j.cell.2020.03.049
Cell · 668 citazioni
TLDR
It is proposed that condensation coupled to conformational rearrangements and heterotypic multivalent interactions may be a general principle underlying RNP granule assembly.