A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
Dan Zhang,Yutong Liu,13 Autori,Pinglong Xu
2022 · DOI: 10.1038/s41556-022-00894-z
Nature Cell Biology · 173 citazioni
TLDR
The findings identify an alternative innate immune pathway and its critical role in organ fibrosis, report an innate immunity-directed translation program and suggest the therapeutic potential for targeting the STING–PERK pathway in treating fibrotic diseases.