Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function
Cameron S. Field,Francesc Baixauli,12 作者,Erika L. Pearce
2019 · DOI: 10.1016/j.cmet.2019.11.021
Cell Metabolism · 引用 323 次
TLDR
It is shown that in Tregs, genetic or pharmacologic inhibition of FABP5 function causes mitochondrial changes underscored by decreased OXPHOS, impaired lipid metabolism, and loss of cristae structure that underlie enhanced immunosuppression in the tumor microenvironment.