Immune checkpoint blockade: a common denominator approach to cancer therapy.
Immune checkpoint blockade: a common denominator approach to cancer therapy.
S. Topalian,C. Drake,D. Pardoll
2015 · DOI: 10.1016/j.ccell.2015.03.001
Cancer Cell · 引用 3,719 次
TLDR
The immune system recognizes and is poised to eliminate cancer but is held in check by inhibitory receptors and ligands, so drugs interrupting immune checkpoints, such as anti-CTLA-4, anti-PD-1, and others in early development, can unleash anti-tumor immunity and mediate durable cancer regressions.