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The DNA damage response: ten years after.
The DNA damage response: ten years after.
J. Harper,S. Elledge,S. Elledge,S. Elledge
2007 · DOI: 10.1016/J.MOLCEL.2007.11.015
Molecules and Cells · 1,731 citations
TLDR
This work has witnessed an explosion in understanding of DNA damage sensing, signaling, and the complex interplay between protein phosphorylation and the ubiquitin pathway employed by the DDR network to execute the response to DNA damage.