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Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.
Discovery of O-Alkylamino Tethered Niclosamide Derivatives as Potent and Orally Bioavailable Anticancer Agents.
Haijun Chen,Zhengduo Yang,6 作者,Jia Zhou
2013 · DOI: 10.1021/ML3003082
ACS Medicinal Chemistry Letters · 引用数 111
TLDR
Compound 11 (HJC0152) has been demonstrated to significantly suppress MDA-MB-231 xenograft tumor growth in vivo, indicating its great potential as efficacious and orally bioavailable therapeutics for human cancer.