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Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d
Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d
Cheng Zhang,S. Konermann,7 Auteurs,D. Lyumkis
2018 · DOI: 10.1016/j.cell.2018.09.001
Cell · 229 citations
TLDR
A comprehensive analysis of Cas13d in diverse enzymatic states facilitated site-specific truncations for minimal size and delineates a blueprint for improving biomolecular applications of RNA targeting.