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Roles for PI(3,5)P2 in nutrient sensing through TORC1
Roles for PI(3,5)P2 in nutrient sensing through TORC1
Natsuko Jin,Kai Mao,8 Auteurs,L. Weisman
2014 · DOI: 10.1091/mbc.E14-01-0021
Molecular Biology of the Cell · 86 citations
TLDR
It is demonstrated that phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a critical upstream modulator of TORC1 activity in yeast and is required forTORC1-dependent regulation of autophagy and nutrient-dependent endocytosis.
Résumé
The protein kinase TORC1 regulates cell growth in response to nutrients. This study demonstrates that phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a critical upstream modulator of TORC1 activity in yeast. In this capacity, PI(3,5)P2 is required for TORC1-dependent regulation of autophagy and nutrient-dependent endocytosis.