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RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
Jordina Guillén-Boixet,Andrii Kopach,20 Auteurs,Titus M. Franzmann
2020 · DOI: 10.1016/j.cell.2020.03.049
Cell · 668 citations
TLDR
It is proposed that condensation coupled to conformational rearrangements and heterotypic multivalent interactions may be a general principle underlying RNP granule assembly.