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7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species.
7,3',4'-Trihydroxyisoflavone modulates multidrug resistance transporters and induces apoptosis via production of reactive oxygen species.
Y. Lo,Wanjen Wang,C. Ho
2012 · DOI: 10.1016/j.tox.2012.08.003
Toxicology · 45 citations
TLDR
It is demonstrated for the first time that 7,3',4'-THIF causes cell death in human cervical cancer cells through the ROS-dependent suppression of MDR transporters and p53-mediated activation of the intrinsic mitochondrial pathway of apoptosis.