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Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology
Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology
Hansruedi Mathys,Zhuyu Peng,27 Autores,Li-Huei Tsai
2023 · DOI: 10.1016/j.cell.2023.08.039
Cell · 261 citas
TLDR
A single-cell transcriptomic atlas of the aged human prefrontal cortex covering 2.3 million cells from postmortem human brain samples of 427 individuals with varying degrees of AD pathology and cognitive impairment identified AD-pathology-associated alterations shared between excitatory neuron subtypes.