Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
G. Tannahill,A. Curtis,30 Autoren,L. O’Neill
2013 · DOI: 10.1038/nature11986
Nature · 3,181 Zitierungen
TLDR
It is shown that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages, and succinate is identified as a metabolite in innate immune signalling, which enhances interleukoethic production during inflammation.