Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells
M. Norelli,B. Camisa,14 Autoren,A. Bondanza
2018 · DOI: 10.1038/s41591-018-0036-4
Nature Medicine · 1,172 Zitierungen
TLDR
A mouse model recapitulating key features of CRS and neurotoxicity is described, and the IL-1 receptor antagonist anakinra abolished both CRSand neurotoxicity, resulting in substantially extended leukemia-free survival.