Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
Zhuo Chen,F. Miao,10 Autoren,R. Natarajan
2016 · DOI: 10.1073/pnas.1603712113
Proceedings of the National Academy of Sciences of the United States of America · 218 Zitierungen
TLDR
Results show that DNA-me differences during the DCCT persist at certain loci associated with glycemia for several years during the EDIC Study and support an epigenetic explanation for metabolic memory.