Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide.
J. Lau,Paw Bloch,14 Autoren,T. Kruse
2015 · DOI: 10.1021/acs.jmedchem.5b00726
Journal of Medicinal Chemistry · 809 Zitierungen
TLDR
The fatty acid moiety and the linking chemistry to GLp-1 were the key features to secure high albumin affinity and GLP-1 receptor (GLP- 1R) potency and in obtaining a prolonged exposure and action of the GLP -1 analogue.