Sirtuins as regulators of metabolism and healthspan
Sirtuins as regulators of metabolism and healthspan
R. Houtkooper,E. Pirinen,J. Auwerx
2012 · DOI: 10.1038/nrm3293
Nature reviews. Molecular cell biology · 1,864 Citações
TLDR
The mammalian sirtuin protein family (comprising SIRT1–SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.