Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer.
Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer.
Huajing Teng,Yan Wang,17 Autores,Q. Zhan
2022 · DOI: 10.1016/j.ccell.2022.11.013
Cancer Cell · 87 Citações
TLDR
The role of intestinal microbiota-mediated nucleotide biosynthesis in the response of rectal tumors to nCRT is unraveled, and the importance of deciphering the cross-talk between cancer cells and gut microorganisms during cancer therapies is highlighted.