Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements
Maxwell R Mumbach,Ansuman T. Satpathy,24 Autores,Howard Y. Chang
2017 · DOI: 10.1038/ng.3963
Nature Genetics · 418 Citações
TLDR
It is shown that H3K27ac HiChIP generates high-resolution contact maps of active enhancers and target genes in rare primary human T cell subtypes and coronary artery smooth muscle cells, providing a principled means of assigning molecular functions to autoimmune and cardiovascular disease risk variants.