A hominid-specific shift in cerebellar expression, upstream retrotransposons, and a potential cis-regulatory mechanism: bioinformatics analyses of the mu-opioid receptor gene
A hominid-specific shift in cerebellar expression, upstream retrotransposons, and a potential cis-regulatory mechanism: bioinformatics analyses of the mu-opioid receptor gene
O. Levran,Eran Even-Tov,Li Zhao
2019 · DOI: 10.1038/s41437-019-0282-3
Heredity · 3 Citações
TLDR
Bioinformatic analysis of the OPRM1 upstream region revealed a functional CTCF-binding region that evolved from tandem insertions of retrotransposons L1P1 and L1PA1 upstream (−60 kb) of O PRM1, and the derived G allele became the major allele in the populations represented in the 1000 Genomes Project and may be beneficial.