Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
Daehwan Kim,Joseph M. Paggi,2 Autores,S. Salzberg
2019 · DOI: 10.1038/s41587-019-0201-4
Nature Biotechnology · 8,999 Citações
TLDR
This work presents a method named HISAT2 (hierarchical indexing for spliced alignment of transcripts 2) that can align both DNA and RNA sequences using a graph Ferragina Manzini index, and uses it to represent and search an expanded model of the human reference genome.